Proteins at Interfaces: Conformational Behavior and Wear

Proteins at interfaces play a major role in biomaterials and lab-on-a-chip devices

Dumont

2013

Scholarcy highlights

  • Proteins at interfaces play a major role in biomaterials and lab-on-a-chip devices
  • Protein interactions with the surface change their conformations and their ability to bind to their respective ligands
  • Wear is the progressive loss of material from an object caused by contact and relative movement of the contacting solid, liquid, or gas
  • We use microtubules gliding on kinesin motor proteins as transporters in biosensors. This system, known as the motility assay, is ideal for studying how the conformation of kinesins impacts the gliding of microtubules and the performance of the biosensor
  • The proposed studies seek to show that kinesins' geometry changes with their grafting density following De Gennes' scaling laws for flexible polymers (Chapter 2, published in Langmuir as E.L.P
  • Random Sequential Adsorption of proteins on polymer-covered surfaces: A simulation-based approach) and I explored a molecular model to explain the fracture of materials at low stresses

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