Interaction of Chronic Daily Warfarin Therapy and Rifampin

To evaluate the interaction between the antibiotic rifampin and the anticoagulant warfarin during chronic therapy, eight normal subjects were given daily doses of warfarin for 21 days to achieve therapeutic hypoprothrombinemia

ROBERT A. O'REILLY

2013

Scholarcy highlights

  • To evaluate the interaction between the antibiotic rifampin and the anticoagulant warfarin during chronic therapy, eight normal subjects were given daily doses of warfarin for 21 days to achieve therapeutic hypoprothrombinemia
  • Contributors must reveal any conflict of interest
  • No significant difference in the warfarin levels was found between the spectrophotometric and chromatographic methods
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