Cholesterol Derivatives Based Charged Liposomes for Doxorubicin Delivery: Preparation, In Vitro and In Vivo Characterization

Our research demonstrated that the charged liposomes incorporating with PEG showed prolonged and improved release profile of DOX, as well as low cytotoxicity and hemolysis

Yu Nie

2013

Scholarcy highlights

  • Liposomes have been widely used in the therapeutic drug delivery, including small molecular drugs, proteins, genes and diagnostic contrast reagents
  • Results showed that after PEGylation, Anionic liposomes and cationic liposomes liposomes displayed prolonged retention release profile, while kept similar size distribution, encapsulation efficiency, low cytotoxicity and hemolysis comparing with neutral liposomes
  • Doxorubicin with property of fluorescence and therapy was successfully encapsulated into charged liposome formulations from cationic and anionic cholesterol derivatives
  • Such liposome formulations can serve as a model platform to further study the in vitro and in vivo behavior with assistance from fluorescent images, fluorescence-activated cell sorting technique and some other classic methods
  • Our research demonstrated that the charged liposomes incorporating with PEG showed prolonged and improved release profile of DOX, as well as low cytotoxicity and hemolysis
  • The experiments showed that there were no significant differences in drug entrapment efficiency among the formulations
  • In vivo tumor inhibition further confirmed that charged liposomes had greater tumor inhibitory effect, indicating both positively and negatively charged PEGylated liposome formulations with modified cholesterol derivatives may be potential drug carriers to improve the therapeutic efficacy

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