Strategies for Image-Guided Therapy, Surgery, and Drug Delivery Using Photoacoustic Imaging

We examine the progress and strategies for development of photoacoustics in these three key areas with an emphasis on the value photoacoustics has for image-guided therapy

Colman Moore

2019

Scholarcy highlights

  • We provide an overview of the emerging roles these PA technologies are playing in image-guided therapy, surgery, and drug delivery
  • With spectroscopic photoacoustic imaging, it is possible to reduce noise from background photoabsorbers using knowledge of their wavelength-specific absorption spectra and relative tissue concentrations to isolate the signal of the exogenous agent
  • Current efforts devoted to synthesizing new fluorophores for optical imaging in the deep NIR will have significant utility for photoacoustic imaging For the time being, payload strategies that incorporate already food and drug administration approved dyes such as methylene blue and indocyanine green may have the quickest path to clinical approval
  • PAI can improve upon current methods for vascular imaging, which have various drawbacks including the use of ionizing radiation, requisite contrast agents, minimum flow velocities, and low penetration depths
  • Li et al reported the development of a novel PA system, Single-Impulse Panoramic Photoacoustic Computed Tomography), which has already been used to image the full mouse body, brain functional connectivity, and track circulating tumor cells in the living vasculature
  • Contrast agents with absorbance maxima at longer wavelengths in the second optical window will be increasingly developed to improve the depths at which photoacoustic imaging is effective

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