Liver and Kidney Dysfunction in Wistar Rats Exposed to Municipal Landfill Leachate

These findings show the potentials of landfill leachate to induce liver and kidney dysfunction in rat probably via free radical formation and/or direct chemical disruption of the organs

Chibuisi G. Alimba; Adekunle A. Bakare; Oluwasanmi O. Aina


Scholarcy highlights

  • Solid waste generation by man is inevitable and landfilling is a common method of managing these wastes worldwide
  • We investigated the hepatotoxic and nephrotoxic effects of municipal landfill leachates in rats
  • Significant decrease in the weekly weight gain of treated rats followed by concomitant increase in both absolute and relative liver and kidney weight gain observed has been implicated with hepatotoxicity and nephrotoxicity
  • It suggests that obstructions of these organs by the leachate constituents, likely the heavy metals, may be responsible for the change in organ weight, due to the role of these organs in sequestering metals immediately following their entry into the body systems
  • Bakare et al. and Li et al. had previously reported that mice exposed to landfill leachate had reduced body weight gain and increased relative liver and kidney weight gain respectively due to chemical toxicity from the leachates
  • This assumption is supported by the findings of Sanchez-Chardi and Nadal and Sanchez-Chardi et al. that bioaccumulation of heavy metals from landfills in white-toothed shrew and wood mouse respectively, is associated with increase relative liver and kidney weight gain
  • Raw leachates obtained from Olusosun and Aba-Eku municipal solid wastes landfills in Lagos and Ibadan, South-western Nigeria induced liver and kidney dysfunctions in Wistar rats

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