Investigation of carbonic anhydrase levels under exercise and hyperthermic stress in rats given L-carnitine

The results of this study indicated that carbonic anhydrase inhibition significantly decreased at L-carnitine + Exercise group 4 and Exercise group 1

Şiktar Erdinccedil

2016

Scholarcy highlights

  • L-carnitine is an amino acid derivative whose primary roles in the human body are in transporting long-chain fatty acids into the mitochondria for use as a fuel and buffering excess acyl-CoA accumulation within mitochondria, and the site of β-oxidation
  • The results of this study indicated that carbonic anhydrase inhibition significantly decreased at L-carnitine + Exercise group 4 and Exercise group 1
  • CA inhibition of L-Carnitine + Exercise group of 38° C decreased significantly according to Exercise group of 38° C.
  • The difference in the capacity to oxidize fatty acids between trained and untrained individuals is due to enhanced cellular FA uptake by the FA-translocase and an increased FA transport into the mitochondria by the L-Carnitine barrier system
  • Carnitine is essential for the transport of the long-chain fatty acids across the inner mitochondrial membrane into the mitochondrial matrix, the site of β-oxidation
  • L-carnitine prevents oxidative stress and regulates nitric oxide, the cellular respiration and the activity of enzymes involved in defense against oxidative damage
  • We may conclude that LCarnitine does not have a protective effect during exercises done under hyperthermic conditions in rats with reduction of carbonic anhydrase activity

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