Plant Phenolic Compounds as Immunomodulatory Agents

This review reveals that phenolic compounds are a rich source of valuable potential therapeutic agents for immune system modulation, but further work needs to be carried out in order to establish therapeutical doses, precise mechanism of action, and optimal ways of administration

Alice Grigore

2017

Scholarcy highlights

  • Immune response is one of the most complex mechanisms of the living body, involving the strong cooperation of a large variety of cell types for defending against any potential dangerous agent
  • The discovery of immunomodulatory agents from medicinal plants devoid of toxic side effects, with enhanced bioavailability and that can be used for a long duration, is of great actuality
  • The concepts of “immunomodulatory,” “anti-inflammatory,” and “antioxidant” are often strongly related, and a review of phenolic compounds action on immune system should be analyzed in a context, revealing their mechanism of action on effector cells and on the system as a whole
  • A flavanone glycoside contained in the juice, showed different immune responses, suggesting that hesperidin displays a suppressive effect on inflammation generated by LPS, while the juice seems to enhance the functions of macrophages associated with antimicrobial activity
  • Several aspects resulted from reviewing the literature: plant extracts are not always well characterized or standardized, making difficult to assign the immunomodulatory effect to a single compound; high concentrations of phenolic compounds are used for in vitro studies, and substances that have proven effective on laboratory scale are often ineffective in clinical trials, often due to bioavailability aspects
  • This review reveals that phenolic compounds are a rich source of valuable potential therapeutic agents for immune system modulation, but further work needs to be carried out in order to establish therapeutical doses, precise mechanism of action, and optimal ways of administration

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