Fruit/Vegetable-Drug Interactions: Effects on Drug Metabolizing Enzymes and Drug Transporters

We review some of the most widely consumed fruits and vegetables to inform healthcare providers of possible nu‐ trient-drug interactions and their potential clinical significance

Lourdes Rodriguez-Fragoso; Jorge Reyes-Esparz


Scholarcy highlights

  • Dietary habits are an important modifiable environmental factor influencing human health and disease
  • It has been reported that black mulberry extract potently inhibits organic anion transporting polypeptides-B function at concentrations that seem to be physiologically relevant in vitro. These results suggest that black raspberry and black mulberry may decrease the plasma concentrations of concomitantly ingested OATP-B sub‐ strate drugs or increase the plasma concentration levels of concomitantly ingested CYP3Asubstrate drugs
  • The significance of interactions between drugs is widely appreciated, little attention has been given to interactions between drugs and nu‐ trients
  • Most of the documented information about the effects of fruit and vegetables on me‐ tabolizing enzymes and drug transporters comes from preclinical studies
  • This review shows evidence of the influ‐ ence of fruit, vegetables or their components on the CYP3A4 enzyme, which metabolizes most drugs used by the human population
  • In a series of studies, Rodeiro and others have shown the effects of mango on drug metabolizing enzymes and drug transporters They found that exposure of hepatocytes to mango extract produced a significant reduction in 7methoxyresorufin-O-demethylase activity and an increase in 7penthoxyresorufin-O-depentylase activity
  • Said ap‐ proach must be systematic in order to a) assess the influence of nutritional status, foodstuffs, or specific nutrients on a drug’s pharmacokinetics and pharmacodynamics, and b) evaluate the influence of a drug on overall nutritional status or the status of a specific nutrient
  • Efforts to elucidate po‐ tential risk of food-drug interactions should be intensified in order to prevent undesired and harmful clinical consequences

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