Nanotechnology and MRI contrast enhancement

Technical advances in nanotechnology are creating novel classes of MRI contrast-enhancing agents

Michael L Matson; Lon J Wilson

2010

Scholarcy highlights

  • Technical advances in nanotechnology are creating novel classes of MRI contrast-enhancing agents
  • These nanomaterials offer much higher relaxivities than most current clinical contrast agents, which translates into greater MRI contrast enhancement
  • These nanoscale agents have the potential to revolutionize in vivo applications of contrast-enhanced MRI since they offer the multiple advantages of low toxicities, extremely high relaxivities and cell internalization capabilities
  • We discuss three types of such contrast agents currently in use or under development for medical imaging: small particles of iron oxide, fullerenes encapsulating Gd3+ ions and single-walled carbon nanotube nanocapsules encapsulating Gd3+ ion clusters
  • This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties

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