Peroxiredoxin-3 Is Involved in Bactericidal Activity through the Regulation of Mitochondrial Reactive Oxygen Species

We investigated the functional effect of Prdx3 in bactericidal activity

Sena Lee; Sae Mi Wi; Yoon Min; Ki-Young Lee

2016

Scholarcy highlights

  • Mitochondria are an important site for the production of mitochondria reactive oxygen species that include hydrogen peroxide, superoxide, singlet oxygen, and the hydroxyl radical
  • Prdx3 Is Involved in Bactericidal Activity interaction between tumor necrosis factor receptor-associated factor 6 and evolutionarily conserved signaling intermediate in Toll leads to ECSIT ubiquitination, resulting in increased mitochondrial and cellular ROS generation
  • Recent reports have shown that mitochondria reactive oxygen species play a pivotal role in macrophage-mediated bactericidal activity
  • Prdx3 is synthesized with a mitochondrial targeting sequence and transferred to mitochondria where it might provide a primary line of defense against hydrogen peroxide produced by the mitochondrial respiratory chain
  • Previous studies have shown that the TRAF6-ECSIT complex induced by TLR4 is critical for macrophagemediated bactericidal activity through the regulation of mROS
  • Having shown that Prdx3KD THP-1 cells had increased mROS, we examined the functional effect of Prdx3 in bactericidal activity
  • The physiological relationship between Prdx3-induced cellular protection against mitochondria reactive oxygen species and bactericidal activity remains unclear, our data may contribute to a better understanding of the phagocytic response for the regulation of intracellular microbes

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