Pharmacological review on Centella asiatica: A potential herbal cure-all

These results indicated that Centella asiatica produced different actions on the various phases of wound repair by exhibiting significant wound healing activity in normal as well as delayed healing models

KashmiraJ Gohil; JagrutiA Patel; AnuradhaK Gajjar

2011

Scholarcy highlights

  • In recent times, focus on plant research has increased all over the world
  • Centella asiatica and its extracts were incorporated into the Indian pharmacopoeia, wherein in addition to wound healing, it was recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever, amenorrhea, and diseases of the female genitourinary tract
  • The extract treated wounds were found to epithelialize faster and the rate of wound contraction was higher, as compared to control wounds. These results indicated that CA produced different actions on the various phases of wound repair by exhibiting significant wound healing activity in normal as well as delayed healing models
  • The aqueous CAE revealed significant antinociceptive activity with both the models similar to aspirin but less potent than morphine and significant antiinflammatory activity comparable to mefenamic acid. These results suggested that the aqueous CA extracts possesses antinociceptive and antiinflammatory activities which justified the traditional use of this plant in the treatment of inflammatory conditions or rheumatism
  • The growing number of herbal preparations in the market, including CA, raised the possibility of complications related to improper use of these products, or the lack of medical supervision along with the likelihood of interactions with the drugs and herbs on simultaneous use
  • Several of the recent cases reported to the special Nutritionals adverse event monitoring System indicated the importance of providing patient counselling on the use of herbal preparations
  • Chronic treatment with Centella asiatica extracts for a period of 25 days, beginning 4 days prior to colchicine administration, significantly attenuated colchicine-induced memory impairment and oxidative damage, besides, significantly reversing the colchicines administered increase in acetylcholinesterase activity

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