Boron as Testicular Toxicant in Mice (Mus domesticus)

This study evaluates the effects in an animal model of high intake of boron on the testis

Eduardo Bustos-Obregón; Christopher Olivares

2013

Scholarcy highlights

  • Evaluation of collagen fibers suggests that Boron produced a degradation of the collagen of the tunica albuginea, causing a decrease in the thickness of it and altering the percentage ratio collagen I/collagen III, a process called collagenolysis
  • The purpose of this study is to evaluate the testis following administration of high doses of boron, in an animal model similar to humans inhabiting the north of Chile, that for many years were affected by a high intake of boron in drinking water
  • Histopathological analysis revealed a significant increase in abnormalities of the seminiferous tubules in the Boron group compared to the control group
  • These changes can be explained by reduced proliferation of spermatogenic cells. It depends on Interstitial cells paracrine function through the action of testosterone on sustentacular cells and germ cells. All this alterations were seen as a disruption of androgen status, associated with a lower epithelial height, disorganization of the epithelium and germ cell detachment in rats exposed to boric acid
  • It was found that Control animal had 13.35% of image area for collagen I, and 0.019% for collagen III, while Boron exposed animal had 11.57% of image area for collagen I, and 2.10% for collagen III
  • The decrease in epithelial height in the group exposed to boron may be due to increased apoptotic index, which can be related to the presence of vacuolization found, suggesting loss of specific junctions between sustentaculars cells and germ cells development
  • This is consistent both with a study in mice, in that the evaluation of the effects of boron at a dose of 12 mg/L had an impact on the consistency of liver connective tissue, where deposition of collagen decreased after exposure to Boron, and produces a change in collagen type I to collagen type III

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