Isobaric tags for relative and absolute quantitation‑based proteomics analysis of the effect of ginger oil on bisphenol A‑induced breast cancer cell proliferation

The results indicated that ginger essential oil ‐Bisphenol A may act through the oxidative phosphory‐lation pathway, decreased the expression of succinate dehydrogenase iron‐sulfur subunit and succinate dehydrogenase cytochrome b560 subunit, affected the tricarbox‐ylic acid cycle and decreased the expression of superoxide dismutase

Dan Lei; Tao Hong; Longxue Li; Lai Chen; Xiaoquan Luo; Qinghua Wu; Zhiyong Liu

2020

Scholarcy highlights

  • Breast cancer is one of the most common malignant tumors among females
  • Following ginger essential oil‐Bisphenol A treatment, the cell viability decreased compared with the BPA group
  • The present study systematically identi‐ fied and analyzed the differences of proteome expression in breast cancer cells treated with ginger essential oil and bisphenol A and BPA alone
  • The re‐sults showed that GEO effectively inhibited the viability of breast cancer cells, which is in accordance with the findings of Karkihave, GEO inhibits CD44/ALDH1, the hall‐marks of breast cancer cells, and BPA promoted the proliferation of MCF‐7 cells, which is consistent with previous research
  • The GEO‐BPA, BPA and GEO treat‐ment groups showed 34, 481 and 210 differentially expressed proteins, respec‐ tively, compared with the control group. These differentially expressed proteins could be used as biomarkers to evaluate the effect of GEO on breast cancer induced by BPA, and to guide future treatment strategies for breast cancer
  • The present study showed that down‐regulation of the protein of succinate dehydrogenase iron‐sulfur subunit, succinate dehydrogenase cytochrome b560 subunit, superoxide dismutase and COX‐2 may be an important factor related to oxidative damage that promotes GEO to treat BPA‐induced breast cancer cells
  • These differentially expressed proteins may be the key to the inhibitory effect of ginger essential oil on Bisphenol A‐induced MCF‐7 cells and showed that the molecular function about energy metabolism underlying this effect

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