Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression

The staining of survivin in the present study showed exclusively nuclear localization

Aggelis Stavropoulos; Michail Varras; Thivi Vasilakaki; Viktoria‑Konstantina Varra; Fani‑Niki Varra; Aikaterini Tsavari; Aphrodite Nonni; Nikolaos Kavantzas; Andreas Lazaris


Scholarcy highlights

  • Endometrial carcinoma is one of the most common malignancies of the female genital tract in developed counties, with its life time risk estimated at 2‐3%
  • The immunohistochemical expression of survivin was examined in 99 endometrial adenocarcinomas from Greek patients
  • Brunner et al, identified the expression of survivin in 45% of cases, Pallares et al in 76%, Chuwa et al in 86% and Lehner et al in 100%. These wide variations in the frequency of survivin expression in endometrial carcinomas could be due to a number of reasons, including geographic location, antibodies used, antibody dilutions, interpretation of staining, heterogeneity of endometrial carcinomas and differences in the immunohistochemichal protocols
  • We investigated the effects of immunohistochemical phosphatase and tensin homolog and p53 expression on the expression of survivin in endometrial carcinomas
  • These findings suggested that the co‐expression of and interaction between survivin and PTEN may play a role in the development of more aggressive endometrial carcinomas
  • No significant differences in immunoreactivity were identified when comparing sections from older paraffin blocks with others from recent blocks, suggesting that activated survivin immunoreactivity is well presented in paraffin‐embedded tissues
  • The present findings suggested the importance of concurrent survivin and p53 expression for the development of endometrial carcinomas
  • A significant correlation was found between the sum staining intensity and scores of survivin and p53 immunopositivity and age of patients, histological type, clinical stage, histological differentiation and presence of fallopian tube and/or ovarian invasion

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