Peroxiredoxin 3 is a novel marker for cell proliferation in cervical cancer

We demonstrated increased expression of peroxiredoxin 3 in CC and provided evidence that Prx3 was upregulated in the cells with active proliferation

JING-XIA HU; QUN GAO; LIANQIN LI

2012

Scholarcy highlights

  • The development of cervical cancer has been causally linked to oncogenes E6 and E7 of high‐risk human papillomaviruses
  • We demonstrated increased expression of peroxiredoxin 3 in CC and provided evidence that Prx3 was upregulated in the cells with active proliferation
  • The pattern of Prx3 expression in CC was consistent with that of Ki67, indicating that Prx3 is a potential marker for cell proliferation
  • High‐risk HPV genomes were reported to preferentially integrate near the c‐myc gene. The latter cooperated with HPV E6/E7 to promote the malignant transformation of cervical epitheliums
  • As a target gene of c‐myc, Prx3 played an important role in mitochondrial homeostasis maintenance and neoplastic transformation
  • Our findings showed that the HPV16 E6/E7 expression was increased and was positively associated with the expression of Prx3 in CC
  • Nonn et al reported that peroxiredoxin 3 played a protective role against drug‐induced oxidative stress and subsequent apoptosis of cancer cells, it would be useful to investigate the significance of Prx3 in the prognosis, recurrence and chemo‐ or radiotherapy‐resistance of CC

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