Antibacterial and Synergistic Activity of Prenylated Chalcone Isolated from the Roots of Sophora flavescens

These findings suggest that THIPMC alone or in combination with antibiotics against methicillin-resistant Staphylococcus aureus might be useful for controlling MRSA infections

Guem-San Lee

2010

Scholarcy highlights

  • 7,9,2′,4′-Tetrahydroxy-8-isopentenyl-5-methoxychalcone, isolated from the roots of Sophora flavescens Ait., was found to be active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, either alone or in combination with ampicillin or gentamicin, vis checkerboard assay
  • The combinations of THIPMC plus AM or GM yielded a fractional inhibitory concentration index ranging from 0.188 to 0.375 μg/mL, thereby indicating a synergistic effect. These findings suggest that THIPMC alone or in combination with antibiotics against MRSA might be useful for controlling MRSA infections
  • vancomycin-resistant enterococci infection was only effectively treated by THIPMC alone

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