A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model

The results showed new perspectives on unexplored characteristics of AKR2 with functional implications

Sara Artigas-Jerónimo; Juan Pastor Comín; Margarita Villar; Marinela Contreras; Pilar Alberdi; Israel León Viera; Leandro Soto; Raúl Cordero; James Valdés; Alejandro Cabezas-Cruz; Agustín Estrada-Peña; José de la Fuente

2020

Scholarcy highlights

  • Biology and art have collaborated before for communication in areas such as human physiology and evolution, even proposing that art may have biological basis
  • The results of this study provided a novel combined scientific and artistic multidisciplinary approach to address challenging questions in molecular biology
  • In addition to cell type-specific differences in AKR/SUB-protein interactions, species-specific differences have been described and require further attention. It has been shown in tick cells that SUB regulome affects multiple biological processes that vary in response to infection with the tick-borne pathogen Anaplasma phagocytophilum
  • As shown previously by genetic approaches, musical ensembles supported the fact that AKR/SUB in different species are evolutionarily related and structurally conserved, and predicted AKR2–protein interactions coinciding with those found by genetic approaches such as the Y2H screening used here
  • The methodological approach proposed here for quantum vaccinomics further advances the potential of the vaccinomics pipeline used before for the identification of candidate protective antigens
  • If combined with network analysis for the integration of interactomics and regulomics datasets and big data machine learning algorithms to identify candidate protective antigens and epitopes, quantum vaccinomics would result in designing chimeric antigens based on protective epitopes in selected interacting domains from vector- and pathogen-derived regulatory proteins
  • Levels corroborated the NF-κB positive regulation by interferon regulatory factor 6 and AKR2–RING finger protein 10 interactions, whereas and was used as a negative control in the protein transfection experiment

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