Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

We focused our attention on the NPs produced by crosslinking CS with TPP; there are other polyelectrolytes that have been used to this intent as well: lecithin, pectin, sodium alginate, etc.

Alexandra Zamboulis

2020

Scholarcy highlights

  • Ocular diseases affect a growing number of people across the globe
  • The mechanism of ionotropic gelation is based on ionic interactions between the positively charged amino groups of CS and anionic small molecules, e.g., sodium sulfate, sodium tripolyphosphate, or anionic polymers, e.g., hyaluronic acid, alginates, chondroitin sulfate, and sodium cellulose sulfate, which causes the formation of inter- and intramolecular crosslinks, resulting in the formation of NPs
  • Numerous applications and different drug delivery systems have been reported in the field of ocular drug delivery with promising results in terms of increased drug bioavailability and improved therapeutic effect
  • CS nanoparticles dominate amongst the different kind of delivery formulations
  • In situ hydrogels are another type of formulation with encouraging results that have the advantage of being instilled as eye drops but that can form a hydrogel with a higher retention time once on the ocular surface
  • The increase of therapeutic efficiency is the primary objective of any drug delivery system; patient’s comfort is almost as critical, since it heavily affects compliance to a treatment
  • It should always be kept in sight when designing a drug delivery system

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