Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

These results suggest omeprazole may decrease zinc absorption by increasing gastric pH, there was no control group and the sample size was small

Emily Mohn; Hua Kern; Edward Saltzman; Susan Mitmesser; Diane McKay


Scholarcy highlights

  • The long-term use of prescription and over the counter drugs can induce subclinical and clinically relevant micronutrient deficiencies which may develop gradually over months or even years
  • Case–control and prospective cohort studies measuring serum B12 in older adults determined the use of Pump Inhibitors for at least 12 months was associated with an increased risk of B12 deficiency
  • Patients in the long-term, high-dose group were reported to have higher taste detection and recognition thresholds, lower plasma zinc levels, and higher urinary zinc excretion compared to controls, suggesting the loss of taste in response to captopril may be associated with decreased zinc status
  • A summary of the evidence related to potential drug–nutrient interactions with use of the most often prescribed medications for commonly diagnosed conditions among U.S adults—including PPIs, NSAIDs, anti-hypertensives, hypercholesterolemics, oral hypoglycemics and corticosteroids, bronchodilators, selective serotonin reuptake inhibitors antidepressants, and Oral Contraceptives—was presented
  • Even though the importance of these interactions has long been recognized, appropriately designed observational and intervention studies examining the role of dietary intervention and/or supplementation in ameliorating the effects of chronic medication use are lacking
  • A 16-week randomized controlled trials that tested the effect of metformin treatment on serum Hcy and vitamin B12 in type 2 diabetes patients found that it increased Hcy by 4% and lowered serum B12 by 14% with no changes observed in the placebo group
  • The summary evidence presented in this review will help inform future research efforts and, guide recommendations for patient care
  • Edward Saltzman, and Susan Mitmesser critically reviewed the manuscript

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