Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes

The results indicate that the sericin protein was efficiently removed from the cocoons; the protein concentration in the dispersion was 0.7 ± 0.1% w/w, which corresponds to an extraction efficiency over the total cocoon mass of 27.0 ± 1.6%

Lorella Giovannelli; Andrea Milanesi; Elena Ugazio; Letizia Fracchia; Lorena Segale

2021

Scholarcy highlights

  • Proteins are considered to be suitable ingredients in the biomedical and cosmetic fields and are used in a variety of skin–care formulations
  • While there is a variety of degumming techniques employed in manufacturing, the high–temperature and high–pressure process allows proteins that are valuable for other purposes to be recovered
  • The purification of sericin from the chemicals involved in other extraction processes is difficult
  • The results indicate that the sericin protein was efficiently removed from the cocoons; the protein concentration in the dispersion was 0.7 ± 0.1% w/w, which corresponds to an extraction efficiency over the total cocoon mass of 27.0 ± 1.6%
  • The profile results may of the analyses show a broad peak in the temperature the carriers
  • The spray–drying of the sericin dispersion containing T and M gave a process yield that was even higher, at more than 50% w/w, which is the landmark value beyond which the process can be defined as successfully performed
  • Trehalose and methyl–β–cyclodextrin, which have been used in this study to prepare sericin powders via the freeze–drying and spray–drying techniques, can be recommended as effective carrier and carrier agents for this protein
  • This powder is currently under deeper evaluation as functional ingredient candidate in rinse–off hair–care preparations, such as masks and conditioners

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