A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics

We argue for the need to incorporate the gender perspective in nutritional genomics studies, present the general context, analyze the differences between sex and gender, as well as the limitations to measuring them and to detecting specific sex-gene or sex-phenotype associations, both at the specific gene level or in genome-wide-association studies

Dolores Corella; Oscar Coltell; Olga Portolés; Mercedes Sotos-Prieto; Rebeca Fernández-Carrión; Judith Ramirez-Sabio; Vicente Zanón-Moreno; Josiemer Mattei; José Sorlí; Jose Ordovas


Scholarcy highlights

  • Another study assessing the male specific region of the human Y chromosome, which has been identified as a candidate for gender-related differences in the development of cardiovascular diseases, found that the TBL1Y(A)
  • We found a significant gene-diet interaction associated with the APOA1 G-A polymorphism
  • In women carriers of the A allele, higher polyunsaturated fatty acid intakes were associated with higher HDL-cholesterol concentrations, whereas the opposite effect was observed in G/G women
  • This influence is not appreciable when studying fasting plasma TGs, it becomes apparent with use of a more sensitive index
  • Conduct a literature review of the topic of interest to be investigated including the gender perspective in order to detect the main results as regards genetic and nutritional factors that have an influence on the outcomes and identify the differences per sex/gender that there may be or the gaps that have still not been investigated at this level
  • The higher perception of sweet was significantly associated with a higher preference for bitter in both, men and women
  • The incorporation of the gender perspective into nutritional genomics studies will contribute to improving the methodology of those studies as well as the validity of results, and will allow us to obtain new knowledge on gene-diet interactions and other associations that may differ in men and women, contributing to making more personalized prevention or treatment possible within the new precision nutrition/precision medicine framework

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