Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches

We provide a critical review of the biomaterials used for nanoencapsulation activities and evaluate their putative role with respect to the biocompatibility of the final product, and the overall contribution to the quality target product profile of the product in order to inform improvement and enhance the application of nanotechnology in modern drug delivery systems

Bwalya A. Witika

2020

Scholarcy highlights

  • The development of smart medicines has arisen for many reasons, including the challenge associated with using compounds that exhibit poor intrinsic solubility, resistance due chronic use and improving the side effect profile(s) through targeted delivery
  • The inclusion of polymers, lipids, and surfactants for the production of nanocarriers for use in medicinal and non-medicinal application has demonstrated that there is a possibility of producing technologies that exhibit advantages over conventional formulations including improved stability, favourable biodistribution profiles, slower drug release rates, lower immunotoxicity and the potential for targeting specific cells
  • The use of nanomaterials is growing and efficient screening methods for toxicity and biocompatibility are needed to reduce the expense of testing and cost of use
  • The size, shape, surface chemistry and degree of aggregation of nanomaterials are key factors that influence the toxicity of technologies and in many cases are an integral part of the critical quality attributes of the carriers
  • These have been investigated and reported for laboratory-scale products and many potentially useful nanomedicines must still transition towards clinical use and application
  • Despite an increased understanding of the interaction of nanomaterials with components of the immune system, many questions still remain and require thorough investigation to ensure that a deeper understanding of this phenomenon is gained

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