LC-MS-Based Metabolomics for the Chemosystematics of Kenyan Dodonaea viscosa Jacq (Sapindaceae) Populations

We propose this idea as the plants that are currently classified as D. viscosa subsp viscosa, growing in the Gazi coast, are more similar in their phytochemical composition to the Nanyuki and Machakos populations that are composed of plants that have been designated to be D. viscosa subsp. angustifolia

Magrate M. Kaigongi; Catherine W. Lukhoba; Purity J. Ochieng‘; Malcolm Taylor; Abiy Yenesew; Nokwanda P. Makunga

2020

Scholarcy highlights

  • Dodonaea viscosa Jacq is a globally distributed medicinal plant and its extracts have been shown to have anticancer activity against breast and lung cancer cell lines
  • Kenya is possibly based on prevailing environmental conditions. This is probably influenced by epigenetic mechanisms which enhance phenotypic plasticity possibly as an adaptation to address the different levels of environmental stresses and in such cases, this can be transmitted successfully to the offspring for numerous generations leading to transgenerational changes that evolve over time. We propose this idea as the plants that are currently classified as D. viscosa subsp viscosa, growing in the Gazi coast, are more similar in their phytochemical composition to the Nanyuki and Machakos populations that are composed of plants that have been designated to be D. viscosa subsp. angustifolia
  • All the pure compounds and extracts from the five populations were tested for antimicrobial activity against the following: Staphylococcus aureus, Escherichia coli, Candida albicans, and un-typed isolate of methicillin resistant Staphylococcus aureus
  • Kenya, where the coastal population is said to be composed of D. viscosa subsp viscosa, whereas the in-country are classified as D. viscosa subsp angustifolia
  • The metabolomics data indicate the Gazi coast population to be chemically similar to the Nanyuki and Machakos populations that are composed of plants that have been designated to be D. viscosa subsp angustifolia
  • The column was eluted with 100% n-hexane followed by increasing polarity of EtOAc in n-hexane starting from 1% to 100% of EtOAc, followed by
  • A revision of the taxonomic classification is recommended as the Narok and Nairobi collections had no relatedness with Nanyuki and Machakos plants that are all currently regarded as subspecies angustifolia
  • The 1 H-13 C-HSQS NMR spectrum of hautriwaic acid lactone observed at 500 MHz in CDCl3 solution at 25 ◦ C, Figure S17

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