Structure-Activity and Lipophilicity Relationships of Selected Antibacterial Natural Flavones and Flavanones of Chilean Flora

These findings provide further evidence that structural requirements should be considered in the series of antibacterial flavonoids and establish a good starting point in the search for new compounds in the rational development of new antibacterial agents

Javier Echeverría

Scholarcy highlights

  • Among natural products, flavonoids are widely distributed in plants, showing a broad range of biological activities, like antioxidant, anticarcinogenic, and antimicrobial effects.The basic flavonoid structure is represented by a C6-C3-C6 carbonated skeleton with different bonds between the phenylpropanoid and acetate units, being classified as isoflavonoids, neoflavonoids, and flavonoids
  • Pinocembrin completely inhibited the growth of S. aureus and B. subtilis, resulting in zero turbidity showed a higher susceptibility than Gram-negative bacteria
  • The antibacterial activity determination in has liquid has of theobserved problem the other hand, the other antibacterial activity determination in liquid media themedia problem of observed opalescence due to the insolubility of the compounds aqueous that solutions that with interfere opalescence due to the insolubility of the compounds in aqueousinsolutions interfere the with thedensity opticalwhen density when bacterial is quantified
  • Gram-negative bacteria, bacteria than as as determined. This may be due to differences in the wall structure between both types determined by by thethe. This may be due to differences in the cellcell wall structure between both types of of bacteria interaction of antibacterial compounds the cytoplasmic membrane defines bacteria
  • The results of antimicrobial activity successfully established a structure-activity relationship, in which the lipophilic characteristic was important for antibacterial activity and oxygenation patterns of flavones were important in selectivity
  • These findings provide further evidence that structural requirements should be considered in the series of antibacterial flavonoids and establish a good starting point in the search for new compounds in the rational development of new antibacterial agents

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