Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity

The present study focused on the identification of the major phenolic secondary metabolites from the aerial parts of Erythrina crista-galli

Naglaa Ashmawy; Mohamed Ashour; Michael Wink; Mohamed El-Shazly; Fang-Rong Chang; Noha Swilam; Ashraf Abdel-Naim; Nahla Ayoub

2016

Scholarcy highlights

  • Phenolic compounds are the most widely distributed secondary metabolites in terrestrial plants.They are typical multi-target compounds exerting multiple biological effects
  • The present study focused on the identification of the major phenolic secondary metabolites from the aerial parts of Erythrina crista-galli
  • Apigenin-7-O-rhamnosyl-6-C-glucoside, a minor compound, was obtained as an amorphous yellow powder, which appeared as a dark purple spot on the Paper chromatography and turned yellow upon exposure to ammonia vapors, under UV light
  • 149.50, 115.35, 118.88, 81.18, 70.36, 73.86, 71.16, 78.69 spectral data were similar to those reported for luteolin-6-C-glucoside, which is, 61.44.The UV and NMR spectral data were reported here for the first time in Erythrina crista-galli
  • Similar to those reported for luteolin-6-C-glucoside, which is reported here for the first time in Erythrina crista-galli
  • The IC50 was determined as the concentration of a sample, which resulted in a 50% reduction in cell viability or inhibition of the biological activity
  • The results showed that among the isolated compounds, apigenin-7-O-rhamnosyl-6-C-glucoside, apigenin-6-C-glucoside, luteolin-6-C-glucoside, apigenin and luteolin exhibit the same binding mode of the lead compound E2, with higher fitting scores
  • The current data give support to the traditional use of the herb in some ailments and warrant further investigations

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