Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers

We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods

Hayet Edziri

2012

Scholarcy highlights

  • The use of plant extracts in medicine, for example against microbial infections, is still very widespread and based on knowledge from traditional medicinal practice
  • Retama species have been reported to contain alkaloids. Flavonoids such as daidzein, vicenin-2, naringenin, apigenin, kaempferol, quercetin and kaempferol-7-O-glucoside are present in the seeds, and daidzein
  • Ampicillin and ofloxacin were used as reference drugs for determination of antimicrobial activities
  • In the past few decades, more microbes have became resistant to commonly used antibiotics. These microbes are responsible for an increased number of infections and expand both the need for antimicrobials and the opportunities for their misuse
  • The microorganisms tested in this study were S. aureus, E. coli, P. aeruginosa, and E. faecalis
  • The two isolated flavonoids showed good antibacterial activity against E. coli and P. aeruginosa and important cytotoxicity against Hep-2 cells. They can possibly be used as antimicrobial agents in new drugs for the therapy of infectious diseases caused by pathogens, and eventually as anticancer drug

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