Melatonin as a Potential Multitherapeutic Agent

This review summarizes the studies carried out by our group on the combined effect of MEL with chemotherapeutic agents on the HL-60 cells used as a model of acute promyelocytic leukemia

Yulia Baburina; Alexey Lomovsky; Olga Krestinina

2021

Scholarcy highlights

  • Melatonin is an indoleamine that is produced by the pineal gland and other organs such as the skin, bone marrow, retina, and gastrointestinal tract
  • We showed that MEL has the ability to suppress the expression of antiapoptotic proteins of the Bcl family and to regulate the expression of proteins considered to be the most important regulators of the mitochondrial permeability transition pore, and cyclic nucleotide -phosphodiesterase)
  • We investigated the combined effect of MEL and chemotherapeutic agents from different pharmacological groups—retinoic acid, cytarabine, and navitoclax—on the proliferation, differentiation, and expression of mitochondrial target proteins in HL-60 cells used as a model of acute promyelocytic leukemia
  • We have shown that an important characteristic of mitochondrial integrity, the value of respiratory control, decreased in rats injected with isoprenaline hydrochloride, while chronic consumption of MEL, which preceded the introduction of ISO, contributing to the prevention of this decrease, while chronic administration of MEL did not affect the respiratory control of mitochondria isolated from 12-month-old rats
  • After 45 min of incubation, H2 O2 production in the mitochondria of rats treated with ISO and MEL was 30% higher and 2.5 times lower than in the control, respectively, which was apparently associated with the acceleration and inhibition of mPTP opening, respectively
  • It binds to known membrane receptors and, through various sigMelatonin is capable of exerting both receptor-dependent and receptor-independent naling It pathways, can have various physiological effects
  • These effects allow melaReceptor-independent effects of MEL are mediated by the ability of MEL and its metabotonin protectROS against wide range of toxins processes that generate highly toxic lites to to scavenge andareactive nitrogen speciesand

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