Mesothelium and Malignant Mesothelioma

In random order, an overview of a number of genes and markers that have been identified as being relevant in the study of mesothelial structures and associated diseases

Emilye Hiriart

2019

Scholarcy highlights

  • Malignant mesothelioma is a neoplasm that originates from mesothelial cells lining the body cavities, including the pleura, peritoneum, pericardium, and tunica vaginalis
  • While no direct association between human exposure to carbon nanotubes and development of malignant pleural mesothelioma have been reported, the fact that both erionite and multiwalled carbon nanoparticles share similarities with asbestos suggests that the morphology and size of the particles are of critical importance in the potential to access the pleural tissue and induce an inflammatory response that can lead to development of MPM
  • The mesothelium is an epithelium derived from the mesoderm and plays a crucial role in the development of organs that develop in the embryonic coelom, including the heart, lungs, and the intestines
  • Mesothelium-derived structures can be affected by a number of pathologies with the most serious pathological conditions being the primary cancers known as mesotheliomas
  • Various genes that are characteristically found in the developing and established mesothelial structures are extremely valuable as markers in the diagnosis of mesotheliomas allowing to discriminate malignant mesotheliomas from, for instance, adenocarcinomas

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