Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities

In this paper we describe various proangiogenic factors in glioma vasculature development

Magdalena Groblewska; Barbara Mroczko


Scholarcy highlights

  • Malignant glioma is among the most common types of primary tumors of the central nervous system
  • The current review discusses the role of various proangiogenic factors in driving glioma progression, as well as various antiangiogenic factors, which are necessary in maintaining an equilibrium between pro- and antiangiogenic processes
  • high-grade gliomas express some transcriptional alterations in angiogenesis-associated factors, such as vascular endothelial growth factors, fibroblast growth factor, and epidermal growth factor, which correlate with neovascularization in human glioblastoma multiforme samples, and the upregulation of these genes may play a role in activating the angiogenic switch
  • Gliomas constitute a highly variegated group of malignant tumors of central nervous system. Their development and progression are strictly related with neoangiogenesis, which is controlled and regulated by numerous factors acting as stimulators or inhibitors of this complex process
  • Tumoral angiogenesis in glioma is characterized by certain mechanisms, which are not observed in physiological formation of normal new vessels
  • These mechanisms include hypoxia-induced angiogenic switch, which results from the alterations in angiogenic signaling pathways within glioma stem cells and allows the transition from low-grade to high-grade tumor
  • These neoangiogenic processes lead to dysfunction of the blood–brain barrier and may result in tumor-related edematic swelling of the brain and dramatic increase of intracranial pressure

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