Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases

The aim of this review is to show the most recent advances in the role played by molecular signaling via nanoparticles and nanomaterials in the diagnosis and treatment of infectious diseases

Clara Colino

2018

Scholarcy highlights

  • Common infectious diseases have been reasonably well controlled by a broad range of anti-infective agents, but recently, due to the massive use of these drugs, new resistant strains have appeared
  • Nanoparticles constitute an interesting platform for theranostic applications
  • Quorum sensing is a stimuli-response chemical communication process correlated with population density that bacteria use to regulate biofilm formation
  • Different methods based on the combination of sensitive techniques such as surface-enhanced Raman spectroscopy, electrochemical methods or fluorescence methods combined with the use of nanoparticles, especially metal nanoparticles, for rapid and sensitive identification of bacteria have been developed
  • By analogy with the application of nanoparticles to diagnostic techniques developed for other viruses and on the basis that miniaturized chips with immobilized antibodies have demonstrated their capacity to detect pM levels of other biomarkers, some authors propose that the miniaturization of electrochemical immune-sensing methodology would be a feasible means to develop devices for rapid and in situ Ebola screening
  • Numerous advances in nanoparticle-based systems for the diagnostic and treatment of bacterial infections have been recently published with potential applications in the fight against multidrug resistant strains and bacterial biofilms, among other areas
  • By analogy with the application of nanoparticles to diagnostic techniques developed for other viruses and on the basis that miniaturized chips with immobilized antibodies have demonstrated their capacity to detect pM levels of other biomarkers , some authors propose that the miniaturization of electrochemical immune-sensing methodology would be a feasible means to develop devices for rapid and in situ Ebola screening

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