Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches

In this review we focused on recent developments in synthesis, characterization, properties, and bio-applications mainly on the antibacterial, antifungal, antiviral, anti-inflammatory, anti-cancer and anti-angiogenic properties of AgNPs in a single platform

Xi-Feng Zhang; Zhi-Guo Liu; Wei Shen; Sangiliyandi Gurunathan

2016

Scholarcy highlights

  • Silver nanoparticles are increasingly used in various fields, including medical, food, health care, consumer, and industrial purposes, due to their unique physical and chemical properties
  • In this review we focused on recent developments in synthesis, characterization, properties, and bio-applications mainly on the antibacterial, antifungal, antiviral, anti-inflammatory, anti-cancer and anti-angiogenic properties of AgNPs in a single platform
  • This review comprehensively addressed synthesis, characterization, and bio-applications of silver nanoparticles, with special emphasis on anticancer activity and its mechanisms and therapeutic approaches for cancer using AgNPs
  • Both academic and industrial research has explored the possibility of using AgNPs as a next-generation anticancer therapeutic agent, due to the conventional side effects of chemo- and radiation therapy
  • AgNPs play an important role in clinical research, several factors need to be considered, including the source of raw materials, the method of production, stability, bio-distribution, controlled release, accumulation, cell-specific targeting, and toxicological issues to human beings
  • The development of AgNPs as anti-angiogenic molecules is one of the most interesting approaches for cancer treatment and other angiogenesis-related diseases; it can overcome poor delivery and the problem of drug resistance. It could provide a new avenue for other angiogenic diseases, such as atherosclerosis, rheumatoid arthritis, diabetic retinopathy, psoriasis, endometriosis, and adiposity

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