Chitosan-Functionalized Mg0.5Co0.5Fe2O4 Magnetic Nanoparticles Enhance Delivery of 5-Fluorouracil In Vitro

The efficient delivery of anti-cancer therapeutics with minimal toxicity in healthy organs or tissues remains an enormous challenge

Sanele Mngadi

2020

Scholarcy highlights

  • The efficient delivery of anti-cancer therapeutics with minimal toxicity in healthy organs or tissues remains an enormous challenge
  • Mg0.5Co0.5Fe2O4 NPs were coated with chitosan and characterized using various analytical techniques. They were investigated for the drug release potential of 5-FU, and cytotoxicities assays were performed in human embryonic kidney, human breast adenocarcinoma and human cervical cancer cells
  • The obtained results were in agreement with previous reports, where the cytotoxic effect of chitosan functionalized Magnetic nanoparticles not
  • 5-fluorouracil was effectively encapsulated by the CS-Mg0.5Co0.5Fe2O4 nanoparticles, with chitosan serving as a functionalizing and stabilizing agent
  • Enhanced and selective anticancer activities were observed for the CS-Mg0.5Co0.5Fe2O4-5FU NPs in both investigated cancer cells compared to the free drug, which is significant for the reduction of the dosage regimen and the prevention of off-target effects
  • It can be inferred that the synthesized chitosan functionalized magnetic nanoparticles are promising nanocarriers, and have the potential to be used as a pH-responsive drug delivery system, which can be targeted to cancer cells under a magnetic field
  • Further studies can be undertaken to explore the mechanisms of cellular uptake among NPs

Need more features? Save interactive summary cards to your Scholarcy Library.