Gold as a Possible Alternative to Platinum-Based Chemotherapy for Colon Cancer Treatment

We have reviewed the most recent advances in the use of gold(I) derivatives and gold nanoparticles in Colorectal cancer therapy

Inés Mármol; Javier Quero; María Jesús Rodríguez-Yoldi; Elena Cerrada

2019

Scholarcy highlights

  • Colorectal cancer is the third most common type of cancer and has become one of the leading causes of death from cancers worldwide
  • The corresponding luminescent complexes derived from coumarines functionalized by a propynyloxy group at the 4- or 7-position or two propynyloxy groups in the 6,7-positions have triggered strong cytotoxicity against HT-29 colon carcinoma, which was attributed to the cation tetraphenylphosphonium and their high inhibition of the enzyme thioredoxin reductase
  • Due to the significant side effects of platinum-containing drugs, along with tumor resistance to treatment, new metal-based compounds have been developed and the data collected and exposed in this work suggest that gold could be a promising alternative in the future
  • Gold complexes interact with proteins that are overexpressed in tumor cells, such as thioredoxin reductase or the proteasome system
  • The role of gold in CRC treatment is not limited to gold(I) complexes, since the use of gold nanoparticles has been shown to enhance the effectiveness of classic therapeutic approaches
  • GNPs can be used in different therapies, such as Photothermal therapy, RT, or photodynamic therapy, and act as carriers to deliver the drugs into the tumoral tissue, as well as being used in diagnosis

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