Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology

We report the available data on induced pluripotent stem cell -derived neurons derived from Parkinson’s Disease patients with identified gene mutations

Sahar Avazzadeh; Jara Maria Baena; Cameron Keighron; Yajaira Feller-Sanchez; Leo R. Quinlan

2021

Scholarcy highlights

  • Parkinson’s Disease is a chronic neurodegenerative disorder characterized by motor and non-motor symptoms, among which are bradykinesia, rigidity, tremor as well as mental symptoms such as dementia
  • It has become possible to recapitulate the myriad of phenotypes underlying the PD pathology by using human induced pluripotent stem cell technology
  • We report the available data on induced pluripotent stem cell-derived neurons derived from PD patients with identified gene mutations
  • We will report on the key phenotypes of the generated iPSC-derived neurons from PD patients with different genetic background
  • We discuss the relationship these cellular phenotypes have to PD pathology and future challenges and prospects for iPSC modelling and understanding of the pathogenesis of PD
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