Modeling Diet-Induced NAFLD and NASH in Rats: A Comprehensive Review

We focus on rat models, especially in the current investigation of the establishment of the dietary model of Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in this species, compiling the different dietary compositions and their impact on histological outcomes and metabolic injuries, as well as external factors influencing the course of liver pathogenesis

Lydie Carreres; Zuzana Macek Jílková; Guillaume Vial; Patrice N. Marche; Thomas Decaens; Hervé Lerat

2021

Scholarcy highlights

  • We focus on rat models, especially on the current investigation in the establishment of the dietary model of Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in this species, compiling the different dietary compositions and their impact on histological outcomes and metabolic injuries, as well as external factors influencing the course of liver pathogenesis
  • With the exception of the methionine- and choline-deficient diet model, dietary models were usually more efficient in triggering liver and systemic pathologies related to NAFLD and NASH in rats than in mice
  • One should keep in mind that these models are difficult to compare and replicate because of divergences in protocol length, diet ingredient origins and composition
  • With the exception of the MCDD model, dietary models were usually more efficient in triggering liver and systemic pathologies related to NAFLD and NASH in rats than in11mice
  • One should keep in mind that these models are difficult to compare and replicate because of divergences in protocol length, diet ingredient origins and composition, genetic backgrounds of the animals, age of of the the animals animals and other uncontrolled parameters
  • With the exception of the methionine- and choline-deficient diet model, dietary models were usually more efficient in triggering liver and systemic pathologies related to Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in rats than in11mice

Need more features? Save interactive summary cards to your Scholarcy Library.