Glutathione S-Transferases in Cancer

This review summarizes newly identified functions of glutathione S-transferases proteins and their roles in the cellular signaling, metabolism, and survival of cancer cells

Rahul Raj Singh; Katie M. Reindl

2021

Scholarcy highlights

  • Glutathione S-transferases are a multigene family of eight dimeric enzymes that are classified based on their amino acid sequences and substrate specificity as alpha, kappa, mu, omega, pi, sigma, theta, and zeta .Depending on their subcellular location, glutathione S-transferases are grouped as cytoplasmic, mitochondrial, or membrane-bound
  • We have previously reported that GST Pi 1 knockdown pancreatic ductal adenocarcinoma
  • Higher protein levels of GST isoforms have been reported in cancer stem cells, which is a primary reason for their drug-resistant phenotype
  • Enzymes are a crucial component of the cellular antioxidant system and play critical roles enzymes are a crucial component of the cellular antioxidant system and play critical roles in maintaining cellular homeostasis
  • GSTP1 can in maintaining cellular homeostasis
  • We suggest that GSTP1, along with a combination of other biomarkers, may identify a high-risk population that is susceptible to developing cancer
  • GST Pi 1 can glutathionylate multiple proteins, including various transcription factors and oncogenes

Need more features? Save interactive summary cards to your Scholarcy Library.