Redox Regulation of PTEN by Peroxiredoxins

We summarized recent studies focusing on the relationship of Prxs and the redox regulation of PTEN

Thang Nguyen Huu; Jiyoung Park; Ying Zhang; Iha Park; Hyun Joong Yoon; Hyun Ae Woo; Seung-Rock Lee

2021

Scholarcy highlights

  • The phosphoinositide-3-kinase/protein kinase B pathway is the critical intracellular signaling in controlling a variety of cellular processes
  • The spotlight of this review is to show the connectionPrxs between and redox regulationofofPTEN
  • PTEN and protein tyrosine phosphatases all antagonize the insulin signaling as they directly interact with PI3K and insulin receptor, and both consist of a cysteine residue in the active site that is highly susceptible to H2 O2 -induced oxidation
  • PTEN is well-known for the negative regulatory function of the PI3K/Akt pathway by dephosphorylating PIP3 to PIP2
  • reactive oxygen species, which can be produced as a secondary messenger of intracellular signaling, has the ability to induce PTEN oxidation, forming an intramolecular disulfide bond and inactivating PTEN phosphatase function
  • The redox regulation of PTEN by Prxs has PTEN is well-known for the negative regulatory function of the PI3K/Akt pathway by dephosphorylating PIP3 to PIP2
  • The main focus of this review is on the redox regulation of PTEN concerning Prxs

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