Anti-Fungal Efficacy and Mechanisms of Flavonoids

This review focuses on various naturally occurring flavonoids and their antifungal activities, modes of action, and synergetic use in combination with conventional drugs

Mohammed Saleh Al Aboody; Suresh Mickymaray

2020

Scholarcy highlights

  • Fungal illness often can be fatal, killing more than 1.5 million a year, and such illnesses have an effect on over a billion peoples in a year
  • Candida albicans is the most ubiquitous species globally, which produces more infectious diseases than the total occurrence of infections produced by C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei
  • Flavonoids and catechins acquired from Brazilian traditional medicinal plants, Eugenia dysenterica, and Pouteria ramiflora that have shown potential antifungal activities against C. tropicalis, C. famata, C. krusei, C. guilliermondii, and C. parapsilosis
  • T. rubrum. flavonoid present inGallic turmeric, which has potential anti-candidal activity against various clinical acid is isolated from acetone fraction of Buchenavia tomentosa that inhibits the proliferation rateisolates of and disrupts h-biofilm abruptly in C. albicans
  • Antifungal activities of fisetin inhibit the growth of C. neoformans, C. gattii, M. gypseum, T. mentagrophytes, T. rubrum, and T. tonsurans with minimum inhibitory concentrations range of 4–128 μg/mL
  • Glabridin is a chief active isoflavane isolated from Glycyrrhiza glabra, and has significant antifungal activities against C. albicans, C. tropicalis C. neoformans, and C. glabratas with MIC values ranging from 16 to 64 μg/mL
  • These flavonoids are capable and efficient in synergetic combination therapy with conventional drugs, which can be more appropriate and supportive for finding novel drug therapies against fungal pathogens

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