Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration

We describe a multifunctional bioactive and resorbable membrane with in-built antioxidant agent catechol for the continuous quenching of free radicals as well as to control inflammatory response, helping to promote the wound-healing process

María Puertas-Bartolomé

2018

Scholarcy highlights

  • To date, substantial research efforts have been directed toward developing wound-dressing materials that promote an effective treatment for skin lesions supporting the complex wound-healing process
  • It can be noticed that the band corresponding to the stretching vibration of the ester group increased with the amount of H units in the copolymer while the band corresponding to the stretching vibration of the carbonyl group of the amide group decreased for the lower content of V units in the copolymer
  • Reactivity ratios of these monomers, which are directly related to the comonomer distribution into the growing copolymeric chains, have been previously determined by Jansen et al for polymerization reactions at low conversions reporting values of rH = 7.3 and rV = 0.01
  • Results obtained in this study indicated that both terpolymers decreased intracellular reactive oxygen species production in vitro in human bone marrow mesenchymal stem cells previously treated with H2O2
  • It was found that both conjugated polymers initially had a strong antioxidant activity which lost some effectiveness with time, independent of the catechol content, as it was observed by the authors in other low molecular catechol-containing polymers when antioxidant experiments were performed in the absence of cells
  • The synthesis of statistical VH copolymers, and the subsequent postpolymerization conjugation reaction with catechol-bearing hydrocaffeic acid molecules, have been successfully carried out providing high molecular weight polymers with enhanced availability of the catechol side groups. These long-arm catechol moieties have been demonstrated to provide a functionalized terpolymer with bioadhesive properties to porcine skin in wet conditions; prevention for UV-induced skin damage; antioxidant properties scavenging the ROS generated by hBMSCs; and attenuation of the inflammatory damage in macrophage cultures
  • All of these properties are key features in the wound-healing process and, we can say that these bioinspired materials can be excellent candidates for application as efficient bioadhesive and bioactive wound dressings promoting and favoring the healing effect

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