Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder – Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study)

We aim to identify biological “genomic” correlates of these three cognitive dimensions of depression

Bernhard T. Baune; Tracy Air


Scholarcy highlights

  • The lifetime prevalence of 15% for major depressive disorder within the general population is among the highest among all mental disorders
  • In a recent pilot investigation of CoFaMS, we reported the involvement of B lymphocyte proliferation and ribosomal S26 transcripts in relation to cognitive dysfunction in remitted major depressive disorder
  • The key hypotheses and aims of the project are: Hypothesis 1: Participants with mood disorders have poorer neuropsychological function in the cognitive dimensions of cognitive function, emotion processing, and social cognition compared to healthy matched controls
  • Depression is a mental disorder that is characterized by a recurrent course of illness in many cases, by clinical and biological heterogeneity contributes largest to the burden of disease
  • Among the symptom clusters of depression, cognitive dimensions are prominent and include emotion processing, cognitive function, and social cognition. These cognitive dimensions as key features of depression appear to be relevant for psychosocial function and present as targets of psychological treatment
  • The CoFaM Study is suited to characterize three major cognitive dimensions of depression with an emphasis on cognitive function, social cognition, and emotion processing in depressed participants compared to healthy controls
  • The CoFaM Study will address this key question by investigating the mediating role of the three cognitive dimensions in functional impairment decline in depression

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