Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

These results suggest that CS are able to increase the sensitivity to thyroid hormones in some tissues, accelerating metamorphosis

Karine Rousseau; Sylvie Dufour; Laurent M. Sachs

2021

Scholarcy highlights

  • The hypothalamic-pituitary-thyroid axis is the neuroendocrine thyrotropic axis, which literally acts on the thyroid gland
  • thyroid hormones can act on various tissues and they negatively feedback on the brain/pituitary axis
  • The expression of glucocorticoid receptors seems to be partly controlled by TH depending on the tissues observed: while in the brain and intestine, treatment with T3 induces a decrease in the expression of GR, the opposite occurs in the tail. These results suggest that CS are able to increase the sensitivity to TH in some tissues, accelerating metamorphosis
  • We have highlighted the roles of TH- and CS-regulated developmental transitions in the innovation, adaptation and plasticity of life cycles in vertebrates
  • He reminds us that “both frogs and mammals undergo a life history transition from aquatic to terrestrial habitat,” involving for the most striking examples, air-breathing thanks to lung maturation and maturation of the intestine to cope with the transition to a new food source
  • Similar TH and CS concentration profiles are observed in certain birds and reptiles at hatching and during molting, as well as in certain teleost fishes at hatching and during larval metamorphosis and smoltification
  • The multiple cross-talks between HPT and hypothalamic-pituitary-adrenal axis/HPI axes represent critical mechanisms by which vertebrates modulate their perinatal/postembryonic development as well as their responses to a changing environment

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