Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and Disease

This review presents current perspectives on the emerging functions of fission protein 1 and their implications in human health and diseases, with an emphasis on Fis1’s role in both endocrine and neurological disorders

Ugochukwu Kelvin Ihenacho; Kelsey A. Meacham; Megan Cleland Harwig; Michael E. Widlansky; R. Blake Hill

2021

Scholarcy highlights

  • Regarded as the cell’s “powerhouse”, mitochondria are found in nearly every human tissue where they are sculpted for numerous essential processes
  • Many outstanding questions need to be answered in order to better understand the many potential activities of fission protein 1 in normal and pathological situations
  • As a TPR containing protein, Fis1 may interact with many other protein partners, and defining these partners would be a significant advance to the field
  • High Fis1 expression raises the question of what the fundamental roles of Fis1 at endogenous or sub-pathological levels are, which could include responding to intracellular changes that require attenuation of mitochondrial function through changes in dynamics
  • The finding that extrinsic apoptosis signals through Fis1-Bap31 interactions at endogenous levels raises the question of what other extracellular signal pathways converge on Fis1 for control of mitochondrial homeostasis
  • Given that Rab proteins can mediate endolysosomal signaling, as well as mitochondrial division, it is intriguing to speculate that perhaps the FIS1/TBC1/RAB axis might be involved in extracellular-to-mitochondria sensing
  • Hispidulin, a flavone derivate found in numerous plant species with possible therapeutic benefits in cancer and oxidative stress, was able to counteract the negative effects of high glucose treatments in a murine podocyte cell model by inducing autophagy and inhibiting apoptosis

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