Humanin and Age-Related Diseases: A New Link?

The goal of this review is to summarize the current understanding of the role of HN in aging and age-related diseases

Zhenwei Gong; Emir Tas; Radhika Muzumdar


Scholarcy highlights

  • Humanin is a novel, 24-amino acid polypeptide with proven effects on cell survival, metabolism, response to stressors, and inflammation in vivo and in vitro
  • Levels of HN are measurable in plasma, cerebrospinal fluid, and seminal fluid indicating that it is a secreted protein, though it is still unclear which tissue(s) contributes to the circulating HN pool
  • Because of the differences in translational machinery between the mitochondria and the cytosol, it will be a 21 amino acid peptide if translation occurs in mitochondria, while cytoplasmic translation will yield a 24-amino acid long polypeptide
  • We showed that HN increases glucose uptake into the β cells, enhances glucose oxidation resulting in an increased glucose stimulated insulin secretion as demonstrated in vivo, in cultured beta cells and in islets isolated from wild type and diabetic mice
  • Non-obese diabetic mouse is an autoimmune model for T1DM; the development of diabetes is time-dependent as age correlates with increased lymphocyte infiltration, decreased beta-cell proliferation, and enhanced sensitivity to glucose-induced β-cell apoptosis
  • Contrary to the potential role of HN in tumorigenesis and metastasis of the cancer cells, Eriksson and colleagues demonstrated that, when HNG is administered with bortezomib, HNG prevented bortezomib-induced bone growth impairment in mice with human tumor xenograft models, without affecting its chemotherapeutic effects

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