The present study aimed to study the effectiveness of diclofenac sodium on some biochemical parameters of male rats
2020
Key concepts
Scholarcy highlights
- Diclofenac is a phenylacetic acid derivative that is specially formulated as a non-steroidal anti-inflammatory drug, They compete with arachidonic acid to bind cycloxygens, resulting in decreased formation of prostaglandins, This decrease effect at least partlyThe name diclofenac derivative from its chemical name: 2-(2,6 dichloranilino) phenylacetic acid, It was first synthesize by Alfred Sallmann and Rudolf Pfister and introduced as Voltarin by Ciba-Geigy in 1973.Diclofenac is absorbed efficiently from the gastrointestinal tract
- The results showed no significant differences in the glucose level of the male rats treated with and of diclofenac sodium groups compared to control group which treated with normal saline, and the rats treated with of diclofenac sodium group showed no significant differences in the glucose when compared with of diclofenac sodium group
- The results showed a significant increase in the cholesterol and triglyceride level of the male rats treated with and of diclofenac sodium groups compared with the control group which treated with normal saline, while the rats treated with of diclofenac sodium group showed significant increase in the cholesterol and triglyceride level when compared with of diclofenac sodium group
- The results showed a significant increase in level of alanine transaminase of the male rats treated with and of diclofenac sodium groups compared with the control group which treated with normal saline, while the rats treated with of diclofenac sodium group showed no significant differences in the level of ALT when compared with of diclofenac sodium group
- The results showed a significant increase in level of aspartate transaminase of the male rats treated with and of diclofenac sodium groups compared with control group which treated with normal saline, while the rats treated with of diclofenac sodium group showed significant increase in the level of AST when compared with of diclofenac sodium group
- The results showed no significant differences in the glucose level of the male rats treated with with and of diclofenac sodium groups compared with the control group which treated with normal saline
- Induction of hepatic injury with diclofenac in rats resulted in severe hepatotoxicity as reflected by an increase in the serum levels of GOT, GPT and ALP, It was observed that Diclofenac sodium elevated all these enzymes significantly, indicating severe hepatic cell necrosis
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