Toll-Like Receptor 4 Gene Polymorphisms in patients withUrinary Tract Infection

Aims:The present study aimed to investigate the association between single nucleotide polymorphisms in the toll-like receptor 4 gene and the incidence of Urinary Tract Infection


Scholarcy highlights

  • Urinary tract infections are considered to be most common infections in humans
  • The present study was aimed to investigate the association of Thr399Ile single nucleotide polymorphisms in toll-like receptor 4 gene with incidence of UTI in Iraqi patients
  • The results of the current study, show the presence of a correlation between the genotypes of the TLR4 gene and the incidence of development Urinary Tract Infection, as the results show the significant difference between patients and healthy controls when genotype Heterozygous with, while the genotype Homozygous show no significant difference between the patients and control group with Table
  • Microorganisms isolated from Gram -ve culture-proven bacteriuric are shown in table.E. coli form the majority of strains isolates 53.06% while pseudomonas aeruginusa; Klebsiella pneumonia; proteus sp.; Represents 18.37%, 14.29%, 8.16% respectively .these finding are different from that of other works .E coli is an important pathogen in urinary tract, uropathogenic strains through possessing adhesion pili and other adhessins that predispose bacterial binding to the urothelium
  • For the above mentioned criteria E. coli took the first rank of isolation from urinary tract infection in this study
  • TLR4 C/T The results of statistical analyses for Toll-like receptor-4 gene polymorphism showed that only one patient had Mutant heterozygous type C/T while all other patients and control subjects showed Wild homozygous type C/C, as shown in table(3). These results indicate that there correlation between polymorphism of Toll-like receptors-4 gene and Urinary Tract Infection
  • Toll-like receptors-4 gene polymorphism may associated with susceptibility Urinary tract infections, but this relationship could vary in different populations and disease types

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