Prevalence of Nontuberculous Mycobacteria in Cystic Fibrosis Clinics, United Kingdom, 2009

We found marked geographic variation in prevalence: Olivier et al found higher rates in coastal centers in the United States, and Roux et al found the highest prevalence in west and southwest France

Paul Seddon

2013

Scholarcy highlights

  • Incidence of pulmonary infection with nontuberculous mycobacteria is increasing among persons with cystic fibrosis
  • NTM have been identified as pulmonary pathogens in immunocompetent middle-aged women with nodular bronchiectasis and older men who smoke with upper lobe cavitation
  • Since the 1990s, NTM have been increasingly isolated from the sputum of patients with cystic fibrosis
  • The Study A single-page questionnaire was sent to the lead CF physician in all UK pediatric and adult CF centers identified by the principal UK CF charity, the Cystic Fibrosis Trust, in 2009
  • Fifteen adult and 17 pediatric centers cultured samples for NTM yearly; most remaining centers tested for NTM only if there was a specific clinical indication
  • The higher prevalence in the south of the United Kingdom could be caused by different sampling rates, but we found no systematic difference in screening policy between different UK regions
  • This will require further research into environmental, microbial, and host factors influencing acquisition and disease progression of nontuberculous mycobacteria in the cystic fibrosis population

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