Prevalence of Nontuberculous Mycobacteria in Cystic Fibrosis Clinics, United Kingdom, 2009

We found marked geographic variation in prevalence: Olivier et al found higher rates in coastal centers in the United States, and Roux et al found the highest prevalence in west and southwest France

Paul Seddon


Scholarcy highlights

  • Incidence of pulmonary infection with nontuberculous mycobacteria is increasing among persons with cystic fibrosis
  • NTM have been identified as pulmonary pathogens in immunocompetent middle-aged women with nodular bronchiectasis and older men who smoke with upper lobe cavitation
  • Since the 1990s, NTM have been increasingly isolated from the sputum of patients with cystic fibrosis
  • The Study A single-page questionnaire was sent to the lead CF physician in all UK pediatric and adult CF centers identified by the principal UK CF charity, the Cystic Fibrosis Trust, in 2009
  • Fifteen adult and 17 pediatric centers cultured samples for NTM yearly; most remaining centers tested for NTM only if there was a specific clinical indication
  • The higher prevalence in the south of the United Kingdom could be caused by different sampling rates, but we found no systematic difference in screening policy between different UK regions
  • This will require further research into environmental, microbial, and host factors influencing acquisition and disease progression of nontuberculous mycobacteria in the cystic fibrosis population

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