Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement

The current treatment of craniopharyngiomas is evolving into one of a multimodal approach in which the aim is disease control and improved preservation of quality of life

Stéphanie Puget; Matthew Garnett; Alison Wray; Jacques Grill; Jean-Louis Habrand; Nathalie Bodaert; Michel Zerah; Mercia Bezerra; Dominique Renier; Alain Pierre-Kahn; Christian Sainte-Rose

2008

Scholarcy highlights

  • The current treatment of craniopharyngiomas is evolving into one of a multimodal approach in which the aim is disease control and improved preservation of quality of life
  • The postoperative morbidity was related to hypothalamic dysfunction
  • There have been no new cases of postoperative hyperphagia, morbid obesity, or behavioral dysfunction in this prospective cohort
  • By using a preoperative classification system to grade hypothalamic involvement and stratify treatment, the authors were able to minimize devastating morbidity. This was achieved by identifying subgroups in which complete resection or subtotal resection, performed by an experienced craniopharyngioma surgeon and with postoperative radiotherapy when necessary, yielded better overall results than the traditional gross-total resection
  • Int J Radiat Oncol Biol Phys58:714–720, 2004)| false

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