IMMUNOLOGICAL PARAMETERS AND CORTISOL LEVELS IN CHILDREN WITH ATOPIC DERMATITIS

The role of individual cytokines in the development of various clinical forms of atopic dermatitis and the effect of cortisol on this process in children have not been sufficiently studied

Tamila V. SOROKMAN; Department of Pediatrics and Medical Genetics of Bukovinian State Medical University

2018

Scholarcy highlights

  • The role of individual cytokines in the development of various clinical forms of atopic dermatitis and the effect of cortisol on this process in children have not been sufficiently studied
  • Persistent atopic dermatitis is found in 50% of adult patients diagnosed at school age4; – the psychosocial aspect: AD, as a chronic disease, significantly impairs the quality of life of the patient and his family, leads to disorders in the emotional sphere and social maladaptation5; – the scientific and practical medical aspects: the pathogenesis of AD can not be considered to be elucidated, the current methods of treatment do not ensure full recovery; – the economic aspect: treatment per a patient with mild, moderate or severe AD costs 330, 818 and 1255 Australian dollars per year respectively and this is higher than the cost of treating children with insulin-dependent diabetes mellitus and asthma
  • The total number of leukocytes in children with AD did not exceed the norm, but it was likely to increase in case of severe course, and the rates were higher than in the control group
  • The subpopulation composition of peripheral blood lymphocytes, according to the differentiation clusters, had certain features depending on the severity of the disease
  • There was a possible decrease in the serum IgA concentration, which was especially expressed during a severe course of the disease, and in the same time there was an increase in the serum IgE and IgE – immunoglobulins concentration in children with AD, which interdepended on the severity of the clinical course of the disease
  • Changes in humoral immunity are accompanied by a decrease in the concentration of IgA, and an increase in IgE and IgG in the blood serum
  • Informed consent was obtained from all the patients included in the study“

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