The effect of macrophage phenotype and surface modification of liposomes on internalization

We have investigated the effects of 14 arginine modifications on liposome characteristics such as size, zeta potential, the internalization of fluorescein with non-activated macrophages and changes in IC50 values on LPS-activated, IL-4 activated and non-activated macrophages

Lilusi Ma

2018

Scholarcy highlights

  • 1.1 Targeted Drug Delivery Drug delivery is a method or process of administering a pharmaceutical active compound to achieve a therapeutic effect in humans or animals
  • From the activated and non-activated data it could be concluded that doxorubicin loaded in modified liposomes alters the IC50 depending on the stimulation of macrophages and can be exploited to improve drug delivery
  • Liposomes were modified with arginine derivatives. These modifications had no influence on particle size and drug loading efficiency
  • Cellular uptake of the liposomes was found to be dependent upon macrophage phenotype and surface modifications
  • This work demonstrates the importance of investigating how liposomes interact with different macrophage types and the ability to preferentially deliver drugs to specific macrophage phenotypes
  • The loading efficiency shows that all liposomes have a loading efficiency of greater than 90%
  • The results claims that liposomes modified with arginine derivation are promising efficient nanoparticle vehicles for delivery to macrophages

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