Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000copolymer

The results demonstrated in vitro that the doxorubicin-encapsulated Fe3O4-PLGA-poly(ethylene glycol) nanoparticles show pH sensitivity and can be applied for targeting extracellular pH and could be an effective carrier for anticancer drugs

Eommolbanin Ebrahimi

2014

Scholarcy highlights

  • Cancer is a class of diseases described by uncontrolled cell growth and this out-of-control cell growth starts with cells in the large intestine
  • Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000 copolymer
  • The content and encapsulation efficiency of doxorubicin in Fe3O4 magnetic nanoparticles modified with PLGA-poly(ethylene glycol) copolymer were determined by the disintegration of nanoparticles in dichloromethane
  • To study the drug release profile of the synthesized doxorubicin-encapsulated Fe3O4 magnetic nanoparticles modified with PLGA-PEG copolymer, 3 mg of drug-encapsulated nanoparticles were dispersed in 30 mL of phosphate- buffered solution
  • Doxorubicin-encapsulated Fe3O4 magnetic nanoparticles modified with PLGA-PEG copolymer were obtained by encapsulation of doxorubicin in the nanoparticles
  • With the large saturation magnetization, the doxorubicin-encapsulated Fe3O4 magnetic nanoparticles modified with PLGA-PEG copolymer could be separated from the reaction medium rapidly and in a magnetic field
  • Within about 10 days, we can consider that drug is released from the Fe3O4-PLGA-poly(ethylene glycol) nanoparticles by a diffusion mechanism in vitro

Need more features? Save interactive summary cards to your Scholarcy Library.